Acquired drug tolerance has been a major challenge in cancer therapy. Recent evidence
has revealed the existence of slow-cycling persister cells that survive drug treatments and
give rise to multi-drug-tolerant mutants in cancer. Cells in this dynamic persister state can
escape drug treatment by undergoing various epigenetic changes, which may result in a
transient metabolic rewiring. In this study, with the use of untargeted metabolomics and
phenotype microarrays, we characterize the metabolic profiles of melanoma persister cells …

Acquired drug tolerance has been a major challenge in cancer therapy. Recent evidence
has revealed the existence of slow-cycling persister cells that survive drug treatments and
give rise to multi-drug-tolerant mutants in cancer. Cells in this dynamic persister state can
escape drug treatment by undergoing various epigenetic changes, which may result in a
transient metabolic rewiring. In this study, with the use of untargeted metabolomics and
phenotype microarrays, we characterize the metabolic profiles of melanoma persister cells …