… We hypothesize that the K3326X variant modifies breast and ovarian cancer risk by altering
the C terminus of BRCA2, resulting in loss of the interaction between FANCD2 and BRCA2 …

… In a consecutive series of 755 probands with hereditary breast and ovarian cancer (HBOC), …
and BRCA2 genes, we identified 103 pathologic mutations in BRCA1 and 111 in BRCA2 (…

… other novel single nucleotide polymorphisms, SNPs, … Ovarian Cancer Association Consortium,
the authors hypothesize that BRCA2 K3326X is likely a low risk allele for ovarian cancer …

… between this BRCA2 variant and the risk of breast, ovarian and prostate … BRCA2 K3326X
variant with an increased risk of developing triple-negative breast and serous ovarian cancers …

… the creation of a stop codon 93 amino acids early (K3326*), is … rs11571833 in breast and
ovarian cancer predisposition using … A recent meta-analysis of prostate cancer GWAS was also …

… that BRCA2 K3326X is likely a low risk allele for ovarian cancer with an OR of 1.22–9.3. …
BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers…

… BRCA2 variant, K3326X, results from mutation of adenosine to thymine at exon 27 in the
BRCA2 … that predisposing carriers of other BRCA2 mutations to breast or ovarian cancer ( 8 ). …

… We hypothesized that this allele could modify breast cancer risk in women with the BRCA2
p.K3326* low… of developing several types of cancer, including breast and ovarian cancer. The …

… BRCA2 predispose to hereditary breast and ovarian cancer (… 999del5 and cancers of the
breast, ovary, prostate, and … As the variant introduces a stop codon in the last exon of the gene, …

… the role of BRCA2 germline mutations in developing ovarian, prostate, and pancreatic … Unlike
the small effect on the risk of breast and ovarian cancers, the BRCA2 p.K3326 mutation has …