Entrepreneurship education has grown tremendously, as has been extensively documented. Entrepreneurship education has expanded in scope, significantly extending across fields in universities and penetrating all levels of educational systems. Moreover, the notion and measurement of engagement have become increasingly important to academics and practitioners. Some researchers have discovered that an approach for increasing engagement in a beneficial way has been established from games. The study adopts a business simulation game (BSG) as a serious game in the Entrepreneurship course to develop students’ self-efficacy, motivation, and engagement. The quasi-experiment was applied to 48 university students. The findings indicate that BSG, based on real challenges in a business environment, allows students to develop their self-efficacy, motivation, and engagement. BSG provides significant opportunities and new alternatives for developing management, leadership, and entrepreneurial skills.