Behaviour of some indicators of oxidative stress in postmenopausal and fertile women
Maturitas, 2006•Elsevier
OBJECTIVE: Unsaturated fatty acids are known to have a crucial role in the pathogenesis of
atherosclerosis. They are very sensitive to oxidation caused by excess free oxygen radicals
and the consequent oxidative status, and it is well known that lipid and lipoprotein
metabolism is markedly altered in postmenopausal women. Oxidative stress is involved in
the pathophysiology of atherosclerosis and our study aim was to assess the presence of
such stress in postmenopausal women. DESIGN: One hundred and one women were …
atherosclerosis. They are very sensitive to oxidation caused by excess free oxygen radicals
and the consequent oxidative status, and it is well known that lipid and lipoprotein
metabolism is markedly altered in postmenopausal women. Oxidative stress is involved in
the pathophysiology of atherosclerosis and our study aim was to assess the presence of
such stress in postmenopausal women. DESIGN: One hundred and one women were …
OBJECTIVE
Unsaturated fatty acids are known to have a crucial role in the pathogenesis of atherosclerosis. They are very sensitive to oxidation caused by excess free oxygen radicals and the consequent oxidative status, and it is well known that lipid and lipoprotein metabolism is markedly altered in postmenopausal women. Oxidative stress is involved in the pathophysiology of atherosclerosis and our study aim was to assess the presence of such stress in postmenopausal women.
DESIGN
One hundred and one women were enrolled in the study. Fifty were fertile (32.5±1.1 years) with regular menses and fifty-one were postmenopausal women (52.1±1.3 years). None of the study cohort had ever used hormone replacement therapy. Malonaldehyde (MDA), 4-hydroxynenal (4-HNE), oxidized lipoproteins (ox LDL) and glutathione peroxidase (GSH-PX) values were determined as we believe they reveal oxidative stress.
RESULTS
MDA, 4-HNE and ox LDL concentrations were higher in postmenopausal than fertile women (p<0.001), while GSH-PX concentrations were significantly higher in fertile women than in postmenopausal subjects (p<0.001).
CONCLUSIONS
Our data revealed the presence of oxidative stress in postmenopausal women.
Elsevier
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