Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps
H Aydogan, A Gurlek, H Parlakpinar, I Askar… - Journal of plastic …, 2007 - Elsevier
BACKGROUND: Reperfusion injury is a phenomenon that occurs when tissues are
subjected to ischaemia for a variable period of time, after which they are reperfused. Many
factors have been implicated in the cause of reperfusion injury including free radicals and
neutrophils. Caffeic acid (3, 4-dihydroxycinnamic acid) phenethyl ester (CAPE) is an active
component of propolis from honeybee; it has anti-inflammatory and immunomodulatory
properties, and protective effects against ischaemia-reperfusion (I/R) injury. We investigated …
subjected to ischaemia for a variable period of time, after which they are reperfused. Many
factors have been implicated in the cause of reperfusion injury including free radicals and
neutrophils. Caffeic acid (3, 4-dihydroxycinnamic acid) phenethyl ester (CAPE) is an active
component of propolis from honeybee; it has anti-inflammatory and immunomodulatory
properties, and protective effects against ischaemia-reperfusion (I/R) injury. We investigated …
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