Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2
Y Zhu, J Li, P Zhang, B Peng, C Li, Y Ming, H Liu - PeerJ, 2023 - peerj.com
Y Zhu, J Li, P Zhang, B Peng, C Li, Y Ming, H Liu
PeerJ, 2023•peerj.comBackground During hepatic ischemia-reperfusion injury, the excessive release of
inflammatory cytokines can activate the intracellular signal transduction cascade to induce
hepatocyte injury. Apoptosis is an important way of cell death after I/R injury. Berberine, a
common quaternary ammonium alkaloid, has anti-inflammatory, anti-oxidative stress, and
anti-apoptotic effects. An increasing number of studies have revealed the importance of non-
coding RNAs, including microRNA, long non-coding RNAs and circular RNAs (circRNAs), as …
inflammatory cytokines can activate the intracellular signal transduction cascade to induce
hepatocyte injury. Apoptosis is an important way of cell death after I/R injury. Berberine, a
common quaternary ammonium alkaloid, has anti-inflammatory, anti-oxidative stress, and
anti-apoptotic effects. An increasing number of studies have revealed the importance of non-
coding RNAs, including microRNA, long non-coding RNAs and circular RNAs (circRNAs), as …
Abstract
Background
During hepatic ischemia-reperfusion injury, the excessive release of inflammatory cytokines can activate the intracellular signal transduction cascade to induce hepatocyte injury. Apoptosis is an important way of cell death after I/R injury. Berberine, a common quaternary ammonium alkaloid, has anti-inflammatory, anti-oxidative stress, and anti-apoptotic effects. An increasing number of studies have revealed the importance of non-coding RNAs, including microRNA, long non-coding RNAs and circular RNAs (circRNAs), as regulators of the effects of berberine.
Purpose
In this study, we investigated the mechanism of berberine against liver ischemia-reperfusion injury in vitro.
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