Bertology meets biology: Interpreting attention in protein language models

J Vig, A Madani, LR Varshney, C Xiong… - arXiv preprint arXiv …, 2020 - arxiv.org
protein Transformer models through the lens of attention. We show that attention: (1) captures
the folding structure of proteins… , a key functional component of proteins, and (3) focuses on …

Linguistically inspired roadmap for building biologically reliable protein language models

MH Vu, R Akbar, PA Robert, B Swiatczak… - Nature Machine …, 2023 - nature.com
… However, being largely black-box models and thus challenging to interpret, current protein
… the pre-trained embeddings, interpreting attention pattern heatmaps and saliency maps), the …

[HTML][HTML] Learning the protein language: Evolution, structure, and function

T Bepler, B Berger - Cell systems, 2021 - cell.com
… in protein language modeling and their applications to downstream protein property … are
needed to encode strong biological priors into protein language models and to increase their …

TransformerGO: predicting proteinprotein interactions by modelling the attention between sets of gene ontology terms

I Ieremie, RM Ewing, M Niranjan - Bioinformatics, 2022 - academic.oup.com
… We expect future research on attention based models to offer more comprehensive analysis
of protein to protein interactions, thorough model interpretation of the semantic similarity at a …

GPCR-BERT: Interpreting Sequential Design of G Protein-Coupled Receptors Using Protein Language Models

S Kim, P Mollaei, A Antony, R Magar… - … and Modeling, 2024 - ACS Publications
… advantage of attention weights and hidden states of the model that are interpreted to extract
… The fine-tuned models demonstrated high accuracy in predicting hidden residues within the …

[PDF][PDF] Advancing protein language models with linguistics: a roadmap for improved interpretability

MH Vu, R Akbar, PA Robert, B Swiatczak… - arXiv preprint arXiv …, 2022 - academia.edu
… , BERTology, a research program dedicated to interpreting the BERT language model, has
… the pre-trained embeddings, interpreting attention pattern heatmaps and saliency maps) can …

Prediction of RNA–protein interactions using a nucleotide language model

K Yamada, M Hamada - Bioinformatics Advances, 2022 - academic.oup.com
… However, existing models are often difficult to interpret and require additional information …
BERTology, intend to elucidate how BERT learns contextual information by analyzing attention, …

Exploring evolution-aware &-free protein language models as protein function predictors

M Hu, F Yuan, K Yang, F Ju, J Su… - Advances in …, 2022 - proceedings.neurips.cc
… the close relationship between Transformer attention and biological features. Following
this, [44] and [29] further studied the interpretability of the attention map as contact map. …

Transformer protein language models are unsupervised structure learners

R Rao, J Meier, T Sercu, S Ovchinnikov, A Rives - Biorxiv, 2020 - biorxiv.org
… We demonstrate that Transformer protein language models learn contacts in the self-attention
maps with state-of-the-art performance. We compare ESM-1b (Rives et al., 2020), a large-…

Learning functional properties of proteins with language models

S Unsal, H Atas, M Albayrak, K Turhan… - Nature Machine …, 2022 - nature.com
attention to combine MSAs and protein language models. Although MSA-Transformer
showed average performance in our benchmarks, it was found to be successful on secondary …