[PDF][PDF] Bilateral, simultaneous rupture of the quadriceps tendon associated with simvastatin

MD Guy Rubin, MD Elias Haddad, MD Tsur Ben-Haim… - 2011 - ima.org.il
MD Guy Rubin, MD Elias Haddad, MD Tsur Ben-Haim, MD Irit Elmalach, MD Nimrod Rozen
2011ima.org.il
Tendon rupture associated with statin therapy is rare. Until 2006, the Food and Drug
Administration's adverse-drugeffects-reporting database had collected data related to 247
cases of statin-related tendon rupture [4]. Beri and co-authors [5] published a case-control
study that found no overall association between the use of statins and tendon rupture,
although in subgroup analysis, statin use was found to be a significant risk factor for tendon
rupture in women. We found no reports of bilateral, simultaneous, spontaneous rupture of …
Tendon rupture associated with statin therapy is rare. Until 2006, the Food and Drug Administration’s adverse-drugeffects-reporting database had collected data related to 247 cases of statin-related tendon rupture [4]. Beri and co-authors [5] published a case-control study that found no overall association between the use of statins and tendon rupture, although in subgroup analysis, statin use was found to be a significant risk factor for tendon rupture in women. We found no reports of bilateral, simultaneous, spontaneous rupture of the quadriceps tendon associated with statin therapy, although bilateral rupture of the Achilles tendon associated with statins had been reported. The patient was evaluated for factors known to cause tendon rupture, including histopathological evaluation for special pathological changes. We were unable to determine any alternative factors, indicating that statin-related tendinous complications may be the cause. We therefore suggest that physicians consider statin-related tendinous complications. corresponding address: dr. g. rubin
ima.org.il
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