Bioactive compounds from Aspergillus niger extract enhance the antioxidant activity and prevent the genotoxicity in aflatoxin B1-treated rats

MA Abdel-Wahhab, AA El-Nekeety, AS Hathout… - Toxicon, 2020 - Elsevier
This study aimed to identify the bioactive compounds of the ethyl acetate extract of
Aspergillus niger SH2-EGY using GC-MS and to evaluate their protective role against
aflatoxin B 1 (AFB 1)-induced oxidative stress, genotoxicity and cytotoxicity in rats. Six
groups of male Sprague-Dawley rats were treated orally for 4 weeks included the control
group, AFB 1-treated group (80 μg/kg bw); fungal extract (FE)-treated groups at low (140) or
high dose (280) mg/kg bw and the groups treated with AFB 1 plus FE at the two tested …
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