The quantity of plastic debris entering the ocean per annum is growing at an alarming rate. Synthetic plastic waste, both macro- and microplastics, enter the marine environment from fishing, coastal tourism, seafood and other marine industries and other plastic products. Plastic pollution has a drastic effect on all aquatic life. The conventional plastics which turn up in seas and oceans are recalcitrant to biodegradation and end up being around for decades and centuries. Marine biota is attracted to plastic due to its colour and odour and through the algae that develop films on floating plastics which are a significant source of food for marine animals. The most obvious and disturbing impact of pollution of the marine ecosystem with macroplastics is the ingestion, suffocation and subsequent death of hundreds of marine species. Bioremediation is a useful strategy for the control of plastic pollution in water bodies. The microbes which live in the vicinity of plastic waste adapt and grow on the surface of plastic as biofilms. They produce catalytic enzymes which can degrade the plastic. However, the extent of biodegradation of the plastic will depend upon its structure and chemical properties. This chapter deals with the biodegradation of macroplastic waste utilising various microbes and the challenges associated with the approach.