Bioinformatic analysis reveals an evolutional selection for DNA: RNA hybrid G-quadruplex structures as putative transcription regulatory elements in warm-blooded …
Recently, we reported the co-transcriptional formation of DNA: RNA hybrid G-quadruplex
(HQ) structure by the non-template DNA strand and nascent RNA transcript, which in turn
modulates transcription under both in vitro and in vivo conditions. Here we present
bioinformatic analysis on putative HQ-forming sequences (PHQS) in the genomes of
eukaryotic organisms. Starting from amphibian, PHQS motifs are concentrated in the
immediate 1000-nt region downstream of transcription start sites, implying their potential role …
(HQ) structure by the non-template DNA strand and nascent RNA transcript, which in turn
modulates transcription under both in vitro and in vivo conditions. Here we present
bioinformatic analysis on putative HQ-forming sequences (PHQS) in the genomes of
eukaryotic organisms. Starting from amphibian, PHQS motifs are concentrated in the
immediate 1000-nt region downstream of transcription start sites, implying their potential role …
[PDF][PDF] Bioinformatic Analysis Reveals an Evolutional Selection for DNA: RNA Hybrid G-Quadruplex Structures as Putative Transcription Regulatory Elements in Warm …
肖姗， 张佳宇， 郑克威， 郝玉华， 谭铮 - 2013 - ir.ioz.ac.cn
Recently, we reported the co-transcriptional formation of DNA: RNA hybrid G-quadruplex
(HQ) structure by the non-template DNA strand and nascent RNA transcript, which in turn
modulates transcription under both in vitro and in vivo conditions. Here we present
bioinformatic analysis on putative HQ-forming sequences (PHQS) in the genomes of
eukaryotic organisms. Starting from amphibian, PHQS motifs are concentrated in the
immediate 1000-nt region downstream of transcription start sites, implying their potential role …
(HQ) structure by the non-template DNA strand and nascent RNA transcript, which in turn
modulates transcription under both in vitro and in vivo conditions. Here we present
bioinformatic analysis on putative HQ-forming sequences (PHQS) in the genomes of
eukaryotic organisms. Starting from amphibian, PHQS motifs are concentrated in the
immediate 1000-nt region downstream of transcription start sites, implying their potential role …
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