[PDF][PDF] Progress in hypoglycemic and lipidlowering drugs

B Li, WX Hu - J Comp Chem, 2018 - pdf.hanspub.org
… 素样肽-1(glucagon-like peptide-1, GLP-1)和葡萄糖依赖性 促胰岛素分泌多肽(… , GIP).DPP-4
可以灭活多种生物活性肽, 包括胰高血糖素样肽-1(GLP-1)和葡萄糖依赖性促胰岛素分泌多肽(GIP). …

The incretin hormone GLP1 and mechanisms underlying its secretion: 肠促胰岛素激素GLP1 及其潜在的分泌机制

L Tian, T Jin - Journal of diabetes, 2016 - Wiley Online Library
… The incretin effect accounts for at least 50% of total insulin secreted after … incretins, namely
glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), GLP-1

[PDF][PDF] 胰高血糖素样肽1 和肠道菌群

金天如 - 中国药理学与毒理学杂志, 2016 - cjpt.magtechjournal.com
… , the incretin hormone glucagon-like peptide 1 (GLP-1) has … GLP- 1 and GIP, while DPP- 4
inhibition in preventing their … that underline GLP-1 secretion as well as the biology of GLP- 1- …

基于胰高血糖素类肽1 受体的2 型糖尿病治疗药物研究进展

张慧敏, 林琳, 陈媛媛, 林忠… - … 临床药理学与治疗学, 2015 - manu41.magtech.com.cn
… 摘要胰高血糖素类肤-1(GLP-1)和葡萄糖依赖 性促胰岛素多肤(GIP)为肠内分泌细胞在机体摄
入… -4)可快速 灭活GLP-1和GTP,因此押制DPP4的活性可增 强GLP-1GIP激素的活性水平,从而…

[PDF][PDF] GLP-1/GIP/Gcg 三受体激动剂改善3xTg-AD 小鼠认知行为和病理特征研究

焦娟娟, 李甜, 董雪帆, 曲雪松, 曹越, 武美娜, 祁金顺 - core.ac.uk
GLP-1/GIP/Gcg receptor triagonist, a monomeric peptide, … GLP-1/GIP/Gcg receptor triagonist
probably become a novel therapeutic strategy for the treatment of AD. Key words: GLP-1/GIP/…

[HTML][HTML] 肠促胰素研究的新视野

张露, 高凌, 毕会民 - 世界华人消化杂志, 2015 - wjgnet.com
Incretins are a group of hormones released into the blood stream by gastrointestinal cells …
, 促使GLP-1GIP的分泌[13]. 体外实验中, 应用SGLT1抑制剂可抑制葡萄糖介导的GLP-1GIP的…

处理神经疾病中的二肽基肽酶IV

G Al-Badri, GM Leggio, G Musumeci… - 中国神经再生研究 …, 2018 - sjzsyj.com.cn
… One of the main known functions of the DPP-IV is to deactivate incretins. The … GIP levels
are increased much more than GLP-1 levels following inhibitor treatment, suggesting that GIP

[PDF][PDF] 促胰岛素释放肽和GLP-1 类似物研究进展

李宗杰, 车巧林, 杨丽萍 - 生命科学研究, 2006 - smkx.hunnu.edu.cn
… 当前国内外的研究主要集中在利用现代基因 工程技术和组合化学的手段改造,修饰GLP)1, GLP)1
类似物和GIP 等肠促胰岛素[1] (incretin)多 肽的结构. 近年来,有关学者又分别从细菌,真 菌,昆虫…

[PDF][PDF] gip克隆,序列分析及其基因表达的调节

杨国坤, 徐双阳, 梁晓敏, 秦超彬, 张艳敏, 孟晓林… - 水产学报, 2022 - china-fishery.cn
… polypeptide,GIP) 作为重要的肠道分泌的肠促胰岛素 (incretin),参与机体的能量稳态调节[2].…
然而,Gip 在鱼类中的研究比较 少.研究发现,斑马鱼的Gip 能够通过哺乳动物 的GLP-1GIP 受体…

胰高血糖素样多肽1—治疗糖尿病的多肽, 是治疗阿尔茨海默病的新希望?

L Li - Neuroscience Bulletin, 2007 - Springer
… biochemistry and physiology of GLP-1, communities between … Among all candidate incretins,
GLP-1 was regard as the most … GIP is aslo a potent stimulator for GLP-1 release in vitro[29]. …