The extracellular matrix (ECM) establishes the basis for the cell's microenvironment
providing structural and mechanical support to cells and tissues, and regulating multiple cell
functions including gene expression, cell cycle, apoptosis, morphogenesis, and migration.
Tumor development can be considered as a process where the cells are subjected to
mutations. However, changes in the microenvironment of tumor cells can strongly impact the
growth, invasion and survival of tumor cells. This specialized microenvironment is known to …