Bioreactor studies of production of mycophenolic acid by Penicillium brevicompactum
Batch and fed-batch fermentation processes for the production of mycophenolic acid (MPA)
were optimized and compared. MPA was produced using the microfungus Penicillium
brevicompactum. Different feeding strategies were assessed in fed-batch fermentations in a
14 L stirred bioreactor. A batch fermentation attained a maximum total (extracellular and
intracellular) MPA concentration of 1.26 g/L after 288 h. The best fed-batch operation
involving a constant-rate feeding of sorbitol (a feeding rate= 0.07 g/min, from 48 h to 240 h) …
were optimized and compared. MPA was produced using the microfungus Penicillium
brevicompactum. Different feeding strategies were assessed in fed-batch fermentations in a
14 L stirred bioreactor. A batch fermentation attained a maximum total (extracellular and
intracellular) MPA concentration of 1.26 g/L after 288 h. The best fed-batch operation
involving a constant-rate feeding of sorbitol (a feeding rate= 0.07 g/min, from 48 h to 240 h) …
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