C12Q 1/6827(2006.01)(52) US CI. CPC C12Q 1/6883 (2013.01); C12N 15/11 (2013.01);
CI2N 2310/3231 (2013.01); C12N 2310/3181 (2013.01); C12Q 1/6827 (2013.01)(57)
ABSTRACT Genetic recognition reagents comprising bivalent nucle obases are provided
that bind two strands of nucleic acid, such as an expanded repeat sequence associated with
an expanded repeat disease. In one example the expanded repeat disease is a polyQ
disease, such as Huntington's disease. Methods of use of the reagents are provided …