[HTML][HTML] Bleeding is increased in amyloid precursor protein knockout mouse
Background Amyloid precursor protein (APP) is highly expressed in platelets. APP is the
precursor to amyloid beta (Aβ) peptides that accumulate in cerebral amyloid angiopathy and
plaques in Alzheimer disease. APP and its metabolites interact with many components of the
coagulation system, and have both anticoagulant and procoagulant properties, but it is
unclear if APP contributes to hemostasis in vivo. Objectives To determine whether APP
contributes to hemostasis in mice, including when inhibitors of coagulation are administered …
precursor to amyloid beta (Aβ) peptides that accumulate in cerebral amyloid angiopathy and
plaques in Alzheimer disease. APP and its metabolites interact with many components of the
coagulation system, and have both anticoagulant and procoagulant properties, but it is
unclear if APP contributes to hemostasis in vivo. Objectives To determine whether APP
contributes to hemostasis in mice, including when inhibitors of coagulation are administered …
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