The kallikrein-kinin system is involved in a variety of physiological and pathological
processes. Components of this system, identified in rat and human brains, can be altered in
neurodegenerative processes such as Alzheimer's disease. Here, we studied kinin release
and its inactivation in rats submitted to chronic cerebroventricular infusion of β-amyloid (Aβ)
peptide. Neurodegeneration was confirmed by histological analysis of brain samples. In
cerebrospinal fluid of animals infused with Aβ, bradykinin concentration was increased, as …