Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission*♦
Appropriate mitochondrial transport and distribution are essential for neurons because of the
high energy and Ca 2+ buffering requirements at synapses. Brain-derived neurotrophic
factor (BDNF) plays an essential role in regulating synaptic transmission and plasticity.
However, whether and how BDNF can regulate mitochondrial transport and distribution are
still unclear. Here, we find that in cultured hippocampal neurons, application of BDNF for 15
min decreased the percentage of moving mitochondria in axons, a process dependent on …
high energy and Ca 2+ buffering requirements at synapses. Brain-derived neurotrophic
factor (BDNF) plays an essential role in regulating synaptic transmission and plasticity.
However, whether and how BDNF can regulate mitochondrial transport and distribution are
still unclear. Here, we find that in cultured hippocampal neurons, application of BDNF for 15
min decreased the percentage of moving mitochondria in axons, a process dependent on …
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