Brain-predicted age difference scores are calculated by subtracting chronological age from
'brain'age, which is estimated using neuroimaging data. Positive scores reflect accelerated
ageing and are associated with increased mortality risk and poorer physical function. To
date, however, the relationship between brain-predicted age difference scores and specific
cognitive functions has not been systematically examined using appropriate statistical
methods. First, applying machine learning to 1359 T1-weighted MRI scans, we predicted the …