… This therapeutic ceiling requires a critical appraisal and highlights the … drug development.
In this Review, we objectively itemise the boundaries of therapeutic efficacy in ulcerative colitis, …

… Proposed strategies to break the therapeutic ceiling in drug development in ulcerative colitis.
… assigning individual IBD patients to distinct molecular subgroups, and for each subgroup a …

… ceiling of IBD treatment. However, data on the efficacy and safety of DTT on Crohn’s disease
and ulcerative colitis … and further drug development and research from an IBD standpoint. …

… comparisons between available drugs. Breaking the therapeutic ceiling of efficacy in UC
will require marked advances in management extending well beyond drug development. …

… Drug discovery has evolved from serendipitous phenotypic breakthroughs, such as sulfasalazine
for ulcerative colitis, … have not breached the current therapeutic ceiling to provide long-…

… Administration for the management of moderately to severely active ulcerative colitis (UC) in
… is a clear need for the development of novel therapies to overcome this therapeutic ceiling. …

… the therapeutic ceiling in current treatment strategies of IBD and … remain in breaking this
therapeutic ceiling: Achieving an … healing in CD and histologic healing in ulcerative colitis (UC). …

… Crohn’s Disease and Ulcerative Colitis will be addressed, by … Therefore, new, and more
effective therapies for IBD are … ceiling that we are now facing, contributing to the ultimate goal …

… innovations, a “therapeutic ceiling” has emerged, … drug development programs. A notable
example is the historical exclusion of many patients with isolated proctitis from ulcerative colitis …

… discovery studies that will help optimize the use of available therapies and break the current
therapeutic ceiling… : Crohn's disease (CD) and ulcerative colitis (UC). Both diseases are …