Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats
S Ahmad, JX Masjoan Juncos… - American Journal …, 2019 - journals.physiology.org
Halogens are widely used, highly toxic chemicals that pose a potential threat to humans
because of their abundance. Halogens such as bromine (Br2) cause severe pulmonary and
systemic injuries; however, the mechanisms of their toxicity are largely unknown. Here, we
demonstrated that Br2 and reactive brominated species produced in the lung and released
in blood reach the heart and cause acute cardiac ultrastructural damage and dysfunction in
rats. Br2-induced cardiac damage was demonstrated by acute (3–24 h) increases in …
because of their abundance. Halogens such as bromine (Br2) cause severe pulmonary and
systemic injuries; however, the mechanisms of their toxicity are largely unknown. Here, we
demonstrated that Br2 and reactive brominated species produced in the lung and released
in blood reach the heart and cause acute cardiac ultrastructural damage and dysfunction in
rats. Br2-induced cardiac damage was demonstrated by acute (3–24 h) increases in …
[HTML][HTML] Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats
Halogens are widely used, highly toxic chemicals that pose a potential threat to humans
because of their abundance. Halogens such as bromine (Br2) cause severe pulmonary and
systemic injuries; however, the mechanisms of their toxicity are largely unknown. Here, we
demonstrated that Br2 and reactive brominated species produced in the lung and released
in blood reach the heart and cause acute cardiac ultrastructural damage and dysfunction in
rats. Br2-induced cardiac damage was demonstrated by acute (3–24 h) increases in …
because of their abundance. Halogens such as bromine (Br2) cause severe pulmonary and
systemic injuries; however, the mechanisms of their toxicity are largely unknown. Here, we
demonstrated that Br2 and reactive brominated species produced in the lung and released
in blood reach the heart and cause acute cardiac ultrastructural damage and dysfunction in
rats. Br2-induced cardiac damage was demonstrated by acute (3–24 h) increases in …
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