New technologies such as the I-BIM (Infrastructure Building Information Modeling) are radically changing the infrastructure design and construction sector. In this study, the I-BIM approach has been used for the design of a portion of the future Bologna’s Red Tramway Line. Starting from the topographical survey of the area, a “federated” model was created, aggregating in a single digital environment all the models inherent to the individual disciplines involved. Interference analysis (Clash Detection) between the various disciplines was performed, subject to the preparation of a coordination matrix and the temporal simulation of the worksite phases (BIM 4D). The results have shown that the I-BIM approach represents a powerful tool for optimizing and validating infrastructure design, allowing users to see how the infrastructure integrates and fits into the real 3D environmental context.