C1q deficiency and autoimmunity: the effects of genetic background on disease expression
DA Mitchell, MC Pickering, J Warren… - The Journal of …, 2002 - journals.aai.org
Gene-targeted C1q-deficient mice have been shown to develop a syndrome reminiscent of
human systemic lupus erythematosus with antinuclear Abs and proliferative
glomerulonephritis. Initial phenotypic analysis conducted in (129× C57BL/6) hybrid mice
showed that background genes were a significant factor for the full expression of the
autoimmune disease. To assess the contribution of background genes in the expression of
the autoimmune phenotype, the disrupted C1qa gene was backcrossed for seven …
human systemic lupus erythematosus with antinuclear Abs and proliferative
glomerulonephritis. Initial phenotypic analysis conducted in (129× C57BL/6) hybrid mice
showed that background genes were a significant factor for the full expression of the
autoimmune disease. To assess the contribution of background genes in the expression of
the autoimmune phenotype, the disrupted C1qa gene was backcrossed for seven …
[引用][C] C1q deficiency and autoimmunity: The effects of genetic background on disease expression
DA Mitchell, HT Cook, M Botto, MJ Walport - Immunopharmacology, 2000 - infona.pl
C1q deficiency and autoimmunity: The effects of genetic background on disease expression …
C1q deficiency and autoimmunity: The effects of genetic background on disease expression …
C1q deficiency and autoimmunity: The effects of genetic background on disease expression …