C6-ceramide in combination with transforming growth factor-β enhances Treg cell differentiation and stable FoxP3 expression in vitro and in vivo
Ceramides, sphingosine-based lipid molecules, are generated mainly from the hydrolysis of
sphingomyelin and play pivotal roles in biological processes including cell growth,
differentiation, and inflammation. In this study, we investigated the effect of exogenous
ceramides on the differentiation of regulatory T (Treg) cells and expression of FoxP3 gene in
Treg cells. A cell-permeable C6-ceramide (C6) was capable of upregulating Treg cell
differentiation when acting together with transforming growth factor-beta (TGF-β), and this …
sphingomyelin and play pivotal roles in biological processes including cell growth,
differentiation, and inflammation. In this study, we investigated the effect of exogenous
ceramides on the differentiation of regulatory T (Treg) cells and expression of FoxP3 gene in
Treg cells. A cell-permeable C6-ceramide (C6) was capable of upregulating Treg cell
differentiation when acting together with transforming growth factor-beta (TGF-β), and this …
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