CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin
Background CCR10 and CCL27 make up the most skin-specific chemokine receptor/ligand
pair implicated in skin allergy and inflammatory diseases, including atopic dermatitis and
psoriasis. This pair is thought to regulate the migration, maintenance, or both of skin T cells
and is suggested to be therapeutic targets for treatment of skin diseases. However, the
functional importance of CCR10/CCL27 in vivo remains elusive. Objective We sought to
determine the expression and function of CCR10 in different subsets of skin T cells under …
pair implicated in skin allergy and inflammatory diseases, including atopic dermatitis and
psoriasis. This pair is thought to regulate the migration, maintenance, or both of skin T cells
and is suggested to be therapeutic targets for treatment of skin diseases. However, the
functional importance of CCR10/CCL27 in vivo remains elusive. Objective We sought to
determine the expression and function of CCR10 in different subsets of skin T cells under …
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