CCR2 signaling restricts SARS-CoV-2 infection
A Vanderheiden, J Thomas, AL Soung… - MBio, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic
pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current
evidence suggests that severe disease is associated with dysregulated immunity within the
respiratory tract. However, the innate immune mechanisms that mediate protection during
COVID-19 are not well defined. Here, we characterize a mouse model of SARS-CoV-2
infection and find that early CCR2 signaling restricts the viral burden in the lung. We find that …
pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current
evidence suggests that severe disease is associated with dysregulated immunity within the
respiratory tract. However, the innate immune mechanisms that mediate protection during
COVID-19 are not well defined. Here, we characterize a mouse model of SARS-CoV-2
infection and find that early CCR2 signaling restricts the viral burden in the lung. We find that …
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