[HTML][HTML] CD11b deficiency exacerbates methicillin-resistant staphylococcus aureus-induced sepsis by upregulating inflammatory responses of macrophages
H Sim, D Jeong, HI Kim, S Pak, B Thapa… - Immune …, 2021 - ncbi.nlm.nih.gov
Macrophages are important for the first line of defense against microbial pathogens. Integrin
CD11b, which is encoded by Itgam, is expressed on the surface of macrophages and has
been implicated in adhesion, migration, and cell-mediated cytotoxicity. However, the
functional impact of CD11b on the inflammatory responses of macrophages upon microbial
infection remains unclear. Here, we show that CD11b deficiency resulted in increased
susceptibility to sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) …
CD11b, which is encoded by Itgam, is expressed on the surface of macrophages and has
been implicated in adhesion, migration, and cell-mediated cytotoxicity. However, the
functional impact of CD11b on the inflammatory responses of macrophages upon microbial
infection remains unclear. Here, we show that CD11b deficiency resulted in increased
susceptibility to sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) …
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages
심현섭， 정대철， 김혜인， 박성원， 권형주， 이근욱 - Immune Network, 2021 - kci.go.kr
Macrophages are important for the first line of defense against microbial pathogens. Integrin
CD11b, which is encoded by Itgam, is expressed on the surface of macrophages and has
been implicated in adhesion, migration, and cell-mediated cytotoxicity. However, the
functional impact of CD11b on the inflammatory responses of macrophages upon microbial
infection remains unclear. Here, we show that CD11b deficiency resulted in increased
susceptibility to sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) …
CD11b, which is encoded by Itgam, is expressed on the surface of macrophages and has
been implicated in adhesion, migration, and cell-mediated cytotoxicity. However, the
functional impact of CD11b on the inflammatory responses of macrophages upon microbial
infection remains unclear. Here, we show that CD11b deficiency resulted in increased
susceptibility to sepsis induced by methicillin-resistant Staphylococcus aureus (MRSA) …
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