CD5 provides viability signals to B cells from a subset of B-CLL patients by a mechanism that involves PKC
G Perez-Chacon, JA Vargas, J Jorda, M Morado… - Leukemia research, 2007 - Elsevier
B-chronic lymphocytic leukaemia (B-CLL) is a heterogeneous disease characterized by an
accumulation of B lymphocytes expressing CD5. To date, the biological significance of this
molecule in B-CLL B cells remains to be elucidated. In this study, we have analysed the
functional consequences of the binding of an anti-CD5 antibody on B-CLL B cells. To this
purpose, we have measured the percentage of viability of B-CLL B cells in the presence or
in the absence of anti-CD5 antibodies and also examined some of the biochemical events …
accumulation of B lymphocytes expressing CD5. To date, the biological significance of this
molecule in B-CLL B cells remains to be elucidated. In this study, we have analysed the
functional consequences of the binding of an anti-CD5 antibody on B-CLL B cells. To this
purpose, we have measured the percentage of viability of B-CLL B cells in the presence or
in the absence of anti-CD5 antibodies and also examined some of the biochemical events …
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