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COGcollator: a web server for analysis of distant relationships between homologous protein families

DV Dibrova, KA Konovalov, VV Perekhvatov… - Biology Direct, 2017 - Springer
DV Dibrova, KA Konovalov, VV Perekhvatov, KV Skulachev, AY Mulkidjanian
Biology Direct, 2017•Springer
Abstract Background The Clusters of Orthologous Groups (COGs) of proteins systematize
evolutionary related proteins into specific groups with similar functions. However, the
available databases do not provide means to assess the extent of similarity between the
COGs. Aim We intended to provide a method for identification and visualization of
evolutionary relationships between the COGs, as well as a respective web server. Results
Here we introduce the COGcollator, a web tool for identification of evolutionarily related …
Background
The Clusters of Orthologous Groups (COGs) of proteins systematize evolutionary related proteins into specific groups with similar functions. However, the available databases do not provide means to assess the extent of similarity between the COGs.
Aim
We intended to provide a method for identification and visualization of evolutionary relationships between the COGs, as well as a respective web server.
Results
Here we introduce the COGcollator, a web tool for identification of evolutionarily related COGs and their further analysis. We demonstrate the utility of this tool by identifying the COGs that contain distant homologs of (i) the catalytic subunit of bacterial rotary membrane ATP synthases and (ii) the DNA/RNA helicases of the superfamily 1.
Reviewers
This article was reviewed by Drs. Igor N. Berezovsky, Igor Zhulin and Yuri Wolf.
Springer
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