COVID19 is an emergent disease of aging

D Santesmasses, JP Castro, AA Zenin… - Aging cell, 2020 - Wiley Online Library
… establish COVID-19 as an emergent disease of aging, and age and age-related diseases as
its … , we propose that COVID-19, and more generally deadly respiratory diseases, should be …

[HTML][HTML] Why does COVID-19 disproportionately affect older people?

AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
aging to the pathogenesis of viruses. In this perspective, we offer potential mechanistic
explanations as to why COVID-19 … The resulting vascular inflammation is emerging as the cause …

Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors

M Farshbafnadi, SK Zonouzi, M Sabahi… - Experimental …, 2021 - Elsevier
… Mechanisms and risk factors associated with disease severity in the elderly with COVID-19.
Aging is associated with ACE-2 overexpression, immune dysregulation, decreased sex …

[HTML][HTML] COVID-19: a challenge to physiology of aging

AG Golubev - Frontiers in physiology, 2020 - frontiersin.org
… and challenges imposed by COVID-19. However, the … of COVID-19 and the prevalent
aging-associated diseases. To achieve a proper balance in public health approaches to COVID-19, …

Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease

SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai - Cells, 2021 - mdpi.com
condition. As postulated throughout this review, we propose that senescence-aging-COVID-19
the world which support the hypothesis that COVID-19 is an emergent disease of aging. …

Implication of aging related chronic neuroinflammation on COVID-19 pandemic

P Bossù, E Toppi, V Sterbini, G Spalletta - Journal of Personalized …, 2020 - mdpi.com
… Overall, the aim of the present review is to obtain a global and synthetic perspective on a
topic of emergent interest in the new field of the COVID-19 pandemic and not to describe …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
coronavirus severe acute respiratory syndrome coronavirus 2 causing the Coronavirus disease
(COVID-19… and deaths is observed within the elderly population, and especially in those …

Aging, inflammaging and immunosenescence as risk factors of severe COVID-19

AM Tizazu, HM Mengist, G Demeke - Immunity & Ageing, 2022 - Springer
… an important role in the pathogenesis of COVID-19 leading to serious clinical outcomes. The
… more common in elderly COVID-19 subjects could be associated with inflamm-aging”, mild-…

Theory and Practice of Aging during the COVID-19 Pandemic

AG Golubev, AV Sidorenko - Advances in Gerontology, 2020 - Springer
COVID-19 can be classified as an emergent disease of aging [31] that appeared in addition
to the diseases typically prevalent in older people, mostly chronic noninfectious diseases, …

Severe COVID-19 and aging: are monocytes the key?

BD Pence - Geroscience, 2020 - Springer
… Here, I review emerging evidence to argue that … in COVID-19. I also describe changes
in monocyte function and phenotype that are characteristic of both aging and severe COVID-19, …