Caffeic acid has antipromastigote activity by apoptosis-like process; and anti-amastigote by TNF-α/ROS/NO production and decreased of iron availability
BT da Silva Bortoleti, F Tomiotto-Pellissier… - Phytomedicine, 2019 - Elsevier
Background Leishmaniasis is a disease caused by protozoan parasites of the Leishmania
genus whose current treatment has high cost, highly toxic, and difficult administration, which
makes it very important to find alternative natural compounds of high efficiency and low cost.
Purpose This study assessed the in vitro effect of caffeic acid (CA) on promastigotes and L.
amazonensis-infected macrophages. Methods Evaluation of the in vitro leishmanicidal
activity of CA against promastigotes and L. amazonensis infected peritoneal macrophages …
genus whose current treatment has high cost, highly toxic, and difficult administration, which
makes it very important to find alternative natural compounds of high efficiency and low cost.
Purpose This study assessed the in vitro effect of caffeic acid (CA) on promastigotes and L.
amazonensis-infected macrophages. Methods Evaluation of the in vitro leishmanicidal
activity of CA against promastigotes and L. amazonensis infected peritoneal macrophages …
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