In this paper we summarize more than a decade of interdisciplinary work at Calakmul, including (1) the mapping project, which has covered more than 30 km2; (2) the excavation project, which has uncovered major structures and tombs in the center of the city; (3) the epigraphic project, whose goal is to study the hieroglyphic texts and relate them to the archaeological evidence; (4) the analysis of the architecture, ceramics, and chipped stone to define sacred and secular activity areas and chronological stages; and (5) a focus on the ecology, hydrology, and paleoclimatology of Calakmul and its environs with the aim of understanding more fully its periods of development and decline.