… calcium flux balance in the presence of Ca waves. This article is part of a Special Issue entitled
“Calcium Signaling in Heart… ► Cardiac cells must be in calcium flux balance on each beat …

… for Ca 2+ flux balance to be maintained with a reduced systolic Ca 2+ transient amplitude.
Also, analysis of Ca 2+ fluxes in this model showed that the shift in balance from SR mediated …

… These flux balance considerations also explain why simply potentiating Ca 2+ release from
… Recent work suggests that flux balance is also important here. In particular, decreasing SR …

… the heart is controlled; and (ii) in the steady state, the cell must be in calcium flux balance on
… from this concept of calcium flux balance (see Eisner et al. 2000, 2009, 2013a for reviews). …

… is for calcium transport across the membranes. Thus, to support these processes, our
heart’… , the intricacies and perplexities of calcium balance in the heart muscle cell are still not …

… This section has given some examples of the importance of flux balance considerations to
understanding changes of contractility. The consequences of flux balance will also be referred …

… of work carried out over several years relating to calcium flux balance in cardiac myocytes
(Terrar, 2024). Here, we reply and show the importance of considering calcium flux balance. …

… dominance of the SR in the normal heart. This shift in competition from … in heart failure. Such
a limitation of SR Ca 2+ loading could also contribute to the mechanical dysfunction in heart …

… An alternative strategy would be for the heart to have a much smaller calcium influx … of
SR calcium content. We conclude that the large sarcolemmal calcium fluxes facilitate rapid …

… C, Illustration of flux balance in control and with depressed sarcoplasmic reticulum (SR)
function. The total Ca 2+ efflux via sodium-calcium exchange (NCX) above control diastolic …