The translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus has
been implicated in the mechanism of glutamate excitotoxicity in cortical neurons and has
been observed in vivo following acute rodent brain injuries. However, the mechanism and
time course of AIF redistribution to the nucleus is highly controversial. Because elevated
intracellular calcium is one of the most ubiquitous features of neuronal cell death, this study
tested the hypothesis that cleavage of AIF by the calcium-activated protease calpain …

Calpain I induces cleavage and release of apoptosis-inducing factor from isolated
mitochondria | CiNii Research … Calpain I induces cleavage and release of apoptosis-inducing
factor from isolated mitochondria …