Canakinumab for the treatment of adult-onset Still's disease
Expert Review of Clinical Immunology, 2020•Taylor & Francis
ABSTRACT Introduction: Adult-onset Still's disease (AOSD) is a rare multisystem
autoinflammatory disorder of unknown etiology, with clinical and biological similarities with
the juvenile form (sJIA). The pivotal role of interleukin (IL)-1 gives rise to the use of IL-1
inhibitors in treating resistant cases. Areas covered: This review focuses on canakinumab, a
fully human anti-IL-1β antibody, as treatment for AOSD. The data obtained from case reports
and case series on AOSD and two double-blind, randomized, placebo-controlled Phase III …
autoinflammatory disorder of unknown etiology, with clinical and biological similarities with
the juvenile form (sJIA). The pivotal role of interleukin (IL)-1 gives rise to the use of IL-1
inhibitors in treating resistant cases. Areas covered: This review focuses on canakinumab, a
fully human anti-IL-1β antibody, as treatment for AOSD. The data obtained from case reports
and case series on AOSD and two double-blind, randomized, placebo-controlled Phase III …
Abstract
Introduction: Adult-onset Still’s disease (AOSD) is a rare multisystem autoinflammatory disorder of unknown etiology, with clinical and biological similarities with the juvenile form (sJIA).
The pivotal role of interleukin (IL)-1 gives rise to the use of IL-1 inhibitors in treating resistant cases.
Areas covered: This review focuses on canakinumab, a fully human anti-IL-1β antibody, as treatment for AOSD. The data obtained from case reports and case series on AOSD and two double-blind, randomized, placebo-controlled Phase III trial on sJIA are analyzed. Efficacy and safety profiles of canakinumab are discussed.
Expert opinion: There is no unanimous consensus on how to treat with IL-1 inhibitors. Many reviews have focused primarily on anakinra, but the accumulating data for canakinumab have emerged. The choice of treatment is a relevant issue for patients and the national health services. The available data for canakinumab indicate that this drug in AOSD patients is effective and well tolerated.
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