… that have used freshly isolated tumor specimens for … solid tumor entities where cancer stem
cells were first identified (colon, breast, brain, and pancreas), evidence for cancer stem cells …

… not now viewed as homogeneous masses of proliferating cells, … of cells that originate from
a single cancer stem cell (CSC). Maintenance of the tumor is also dependent on a stromal cell …

… The cancer stem cell (CSC) hypothesis is an attractive model to account … solid tumours. It
proposes a hierarchical organization of cells within the tumour, in which a subpopulation of stem…

… we think of solid tumor biology; however, it is crucial to emphasize that much more work is
needed to better understand how these cells function to initiate and sustain tumor growth. It is …

… Cancer stem cells have been identified and characterized in many solid tumors. ► Breast,
brain and colon cancer stem cells are the most well-characterized. ► Hh, Notch and Wnt …

… tumors to grow, invade, and seed metastatic lesions. The challenges involved in identifying
a CSC population from a solid tumor, … understanding the biological properties of these cells. …

… The attempt to eradicate CSCs/TICs in human solid tumours is a major objective of this
research; academic or company-supported clinical trials are ongoing but mainly by the molecular …

… also suggests the presence of stem cells in solid tumors, there remain many uncertainties, …
proportion of cells in solid tumors are specific cancer stem cells and that these cells can be …

… cancer stem cells. Further on, we reflect the present discussion about the existence of cancer
stem cells in solid tumors as well as the amount and characteristics of tumor-initiating cells …

… most aggressive and metastatic cancers. On the other … cancer cells into phenotypically
distinct subpopulations. In the present review, recent papers published on CSCs in solid tumors (…