Cap-and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs
IN Shatsky, SE Dmitriev, IM Terenin, DE Andreev - Molecules and cells, 2010 - Springer
During the last decade the concept of cellular IRES-elements has become predominant to
explain the continued expression of specific proteins in eukaryotic cells under conditions
when the cap-dependent translation initiation is inhibited. However, many cellular IRESs
regarded as cornerstones of the concept, have been compromised by several recent works
using a number of modern techniques. This review analyzes the sources of artifacts
associated with identification of IRESs and describes a set of control experiments, which …
explain the continued expression of specific proteins in eukaryotic cells under conditions
when the cap-dependent translation initiation is inhibited. However, many cellular IRESs
regarded as cornerstones of the concept, have been compromised by several recent works
using a number of modern techniques. This review analyzes the sources of artifacts
associated with identification of IRESs and describes a set of control experiments, which …
[PDF][PDF] Cap-and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular...
SE Dmitriev, I Terenin, D Andreev - Mol. Cells, 2010 - academia.edu
During the last decade the concept of cellular IRES-elements has become predominant to
explain the continued expression of specific proteins in eukaryotic cells under conditions
when the cap-dependent translation initiation is inhibited. However, many cellular IRESs
regarded as cornerstones of the concept, have been compromised by several recent works
using a number of modern techniques. This review analyzes the sources of artifacts
associated with identification of IRESs and describes a set of control experiments, which …
explain the continued expression of specific proteins in eukaryotic cells under conditions
when the cap-dependent translation initiation is inhibited. However, many cellular IRESs
regarded as cornerstones of the concept, have been compromised by several recent works
using a number of modern techniques. This review analyzes the sources of artifacts
associated with identification of IRESs and describes a set of control experiments, which …
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