TSV-to-TSV coupling is known to be a significant detriment to signal integrity in three-dimensional (3D) IC architectures. Designing a reliable Through-Silicon Via is critical in order to support better performance. This paper explores the challenges brought on by capacitive and inductive TSV-to-TSV coupling in TSV-based 3D ICs. Based on our analyses, we propose two approaches to mitigate these effects. In one approach, a novel coding technique that adjusts the current flow pattern is proposed to mitigate the inductive coupling effects. In another approach an alternative architecture, wrapping around the TSVs, is proposed to greatly reduce the capacitive coupling effect. The efficiency of the proposed coding methods and supporting architectures is demonstrated by comprehensive simulations at both the hardware and system levels.