Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of
anticancer therapies. The biochemical rationale behind many of these phenomena resides
in the activation of transcription factors such as hypoxia-inducible factor 1 and 2 (HIF-1/2). In
turn, the HIF pathway activates a number of genes including those involved in glucose
metabolism, angiogenesis, and pH regulation. Several carbonic anhydrase (CA, EC 4.2. 1.1) …
biochemical and physiological changes, which frequently influence the outcome of
anticancer therapies. The biochemical rationale behind many of these phenomena resides
in the activation of transcription factors such as hypoxia-inducible factor 1 and 2 (HIF-1/2). In
turn, the HIF pathway activates a number of genes including those involved in glucose
metabolism, angiogenesis, and pH regulation. Several carbonic anhydrase (CA, EC 4.2. 1.1) …
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