location of common human diseases. From a sample of 26,142 European-ancestry
participants, we estimated functional aortic valve area by planimetry from prospectively
obtained cardiac MRI sequences of the aortic valve. A genome-wide association study of
aortic valve area in these UK Biobank participants showed two significant associations
indexed by rs71190365 (chr13: 50764607, DLEU1, p= 1.8× 10− 9) and rs35991305 (chr12 …
Background-The aortic valve is an important determinant of cardiovascular physiology and
anatomic location of common human diseases. Methods-From a sample of 34,287 white
British-ancestry participants, we estimated functional aortic valve area by planimetry from
prospectively obtained cardiac MRI sequences of the aortic valve. Aortic valve area
measurements were submitted to genome-wide association testing, followed by polygenic
risk scoring and phenome-wide screening to identify genetic comorbidities. Results-A …