Cardiac imaging of aortic valve area from 26,142 UK Biobank participants reveal novel genetic associations and shared genetic comorbidity with multiple disease …

A Córdova-Palomera, C Tcheandjieu, J Fries, P Varma… - medRxiv, 2020 - medrxiv.org
The aortic valve is an important determinant of cardiovascular physiology and anatomic
location of common human diseases. From a sample of 26,142 European-ancestry
participants, we estimated functional aortic valve area by planimetry from prospectively
obtained cardiac MRI sequences of the aortic valve. A genome-wide association study of
aortic valve area in these UK Biobank participants showed two significant associations
indexed by rs71190365 (chr13: 50764607, DLEU1, p= 1.8× 10− 9) and rs35991305 (chr12 …

[PDF][PDF] Cardiac Imaging of Aortic Valve Area from 34,287 UK Biobank Participants Reveal Novel Genetic Associations and Shared Genetic Comorbidity with Multiple …

JR Priest - researchgate.net
Background-The aortic valve is an important determinant of cardiovascular physiology and
anatomic location of common human diseases. Methods-From a sample of 34,287 white
British-ancestry participants, we estimated functional aortic valve area by planimetry from
prospectively obtained cardiac MRI sequences of the aortic valve. Aortic valve area
measurements were submitted to genome-wide association testing, followed by polygenic
risk scoring and phenome-wide screening to identify genetic comorbidities. Results-A …
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