Cardiorespiratory effects induced by 2-nitrate-1, 3-dibuthoxypropan are reduced by nitric oxide scavenger in rats
TM Queiroz, LG Mendes-Júnior, DD Guimarães… - Autonomic …, 2014 - Elsevier
The search for new nitric oxide donors is warranted by the limitations of organic nitrates
currently used in cardiology. The new organic nitrate 2-nitrate-1, 3-dibuthoxypropan (NDBP)
exhibited promising cardiovascular activities in previous studies. The aim of this study was to
investigate the cardiorespiratory responses evoked by NDBP and to compare them to the
clinically used organic nitrate nitroglycerine (NTG). Arterial pressure, heart rate and
respiration were recorded in conscious adult male Wistar rats. Bolus iv injection of NDBP (1 …
currently used in cardiology. The new organic nitrate 2-nitrate-1, 3-dibuthoxypropan (NDBP)
exhibited promising cardiovascular activities in previous studies. The aim of this study was to
investigate the cardiorespiratory responses evoked by NDBP and to compare them to the
clinically used organic nitrate nitroglycerine (NTG). Arterial pressure, heart rate and
respiration were recorded in conscious adult male Wistar rats. Bolus iv injection of NDBP (1 …
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