Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus
M Gonzalez-Gronow, M Cuchacovich, R Francos… - Journal of …, 2015 - Elsevier
Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins
expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD
patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no
autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade
MBP in vitro. They also induce a decrease in long-term potentiation in the hippocampi of rats
either perfused with or previously inoculated with this IgA. Because this class of …
expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD
patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no
autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade
MBP in vitro. They also induce a decrease in long-term potentiation in the hippocampi of rats
either perfused with or previously inoculated with this IgA. Because this class of …