Catecholamine Release–Inhibitory Peptide Catestatin (Chromogranin A352–372) Naturally Occurring Amino Acid Variant Gly364Ser Causes Profound Changes in …
Background—Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to
the catecholamine release–inhibitory fragment catestatin. We identified a natural
nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and
blood pressure. Methods and Results—Gly364Ser heterozygotes and controls underwent
physiological and biochemical phenotyping, including catecholamine production,
chromogranin A precursor, and its catestatin product. Case-control studies replicated effects …
the catecholamine release–inhibitory fragment catestatin. We identified a natural
nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and
blood pressure. Methods and Results—Gly364Ser heterozygotes and controls underwent
physiological and biochemical phenotyping, including catecholamine production,
chromogranin A precursor, and its catestatin product. Case-control studies replicated effects …
[PDF][PDF] Catecholamine Release–Inhibitory Peptide Catestatin (Chromogranin A352–372)
NOAAV Gly364Ser, C Profound - 2007 - Citeseer
Background—Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to
the catecholamine release–inhibitory fragment catestatin. We identified a natural
nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and
blood pressure. Methods and Results—Gly364Ser heterozygotes and controls underwent
physiological and biochemical phenotyping, including catecholamine production,
chromogranin A precursor, and its catestatin product. Case-control studies replicated effects …
the catecholamine release–inhibitory fragment catestatin. We identified a natural
nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and
blood pressure. Methods and Results—Gly364Ser heterozygotes and controls underwent
physiological and biochemical phenotyping, including catecholamine production,
chromogranin A precursor, and its catestatin product. Case-control studies replicated effects …
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