Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic β-cells
AK Nevins, DC Thurmond - Journal of Biological Chemistry, 2006 - ASBMB
The cycling of the small Rho family GTPase Cdc42 is required for insulin granule exocytosis,
although the regulatory proteins involved in Cdc42 cycling in pancreatic β-cells are
unknown. Here we demonstrate that the caveolar protein caveolin-1 (Cav-1) is a Cdc42-
binding protein in β-cells. Cav-1 associated with Cdc42-VAMP2-bound granules present
near the plasma membrane under basal conditions. However, stimulation with glucose
induced the dissociation of Cav-1 from Cdc42-VAMP2 complexes, coordinate with the timing …
although the regulatory proteins involved in Cdc42 cycling in pancreatic β-cells are
unknown. Here we demonstrate that the caveolar protein caveolin-1 (Cav-1) is a Cdc42-
binding protein in β-cells. Cav-1 associated with Cdc42-VAMP2-bound granules present
near the plasma membrane under basal conditions. However, stimulation with glucose
induced the dissociation of Cav-1 from Cdc42-VAMP2 complexes, coordinate with the timing …
以上显示的是最相近的搜索结果。 查看全部搜索结果