Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-
dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae,
Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S phase, for
subsequent multisite phosphorylation and protein degradation. Cdc6 accumulates in mitosis
and is tightly bound by Clb2 through N-terminal phosphorylation in order to prevent
premature origin licensing and degradation. It has been extensively studied how Cdc6 …
dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae,
Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S phase, for
subsequent multisite phosphorylation and protein degradation. Cdc6 accumulates in mitosis
and is tightly bound by Clb2 through N-terminal phosphorylation in order to prevent
premature origin licensing and degradation. It has been extensively studied how Cdc6 …
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