Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation
B Uranbileg, H Yamamoto, J Park, AR Mohanty… - Journal of Biological …, 2012 - ASBMB
In mammalian cells Cdk2 activity during the G 1-S transition is mainly controlled by p27
KIP1. Although the amount and subcellular localization of p27 influence Cdk2 activity, how
Cdk2 activity is regulated during this phase transition still remains virtually unknown. Here
we report an entirely new mechanism for this regulation. Cdc6 the AAA+ ATPase, known to
assemble prereplicative complexes on chromosomal replication origins and activate p21
CIP1-bound Cdk2, also activated p27-bound Cdk2 in its ATPase and cyclin binding motif …
KIP1. Although the amount and subcellular localization of p27 influence Cdk2 activity, how
Cdk2 activity is regulated during this phase transition still remains virtually unknown. Here
we report an entirely new mechanism for this regulation. Cdc6 the AAA+ ATPase, known to
assemble prereplicative complexes on chromosomal replication origins and activate p21
CIP1-bound Cdk2, also activated p27-bound Cdk2 in its ATPase and cyclin binding motif …
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