The mesoderm is one of the three germ layers produced during gastrulation from which
muscle, bones, kidneys, and the cardiovascular system originate. Understanding the
mechanisms that control mesoderm specification could inform many applications, including
the development of regenerative medicine therapies to manage diseases affecting these
tissues. Here, we used human pluripotent stem cells to investigate the role of cell cycle in
mesoderm formation. To this end, using small molecules or conditional gene knockdown, we …