Central chemoreceptor drive to breathing in unanesthetized toads, Bufo paracnemis

LGS Branco, ML Glass, A Hoffmann - Respiration physiology, 1992 - Elsevier
Central chemoreceptor drive to breathing was studied in unanesthetized toads, equipped
with face masks to measure pulmonary ventilation and arterial catheters to analyze blood
gases. Two series of experiments were performed. Expt. 1: The fourth cerebral ventricle was
perfused with solutions of mock CSF, adjusted to stepwise decreasing pH values.
Concomitant perfusion-induced increases of pulmonary ventilation, pHa and Pa O 2 were
measured. Expt. 2: Inspiration of hypercapnic gas mixtures was applied to stimulate both …
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