Raised blood pressure is the leading attributable risk factor for global morbidity and
mortality. Real world data demonstrates that half of treated patients are at elevated
cardiovascular risk because of inadequately controlled BP. In addition to pharmacotherapy,
certain interventional strategies to reduce blood pressure and cardiovascular risk in
hypertension can be considered according to international guidelines. One of the newer
technologies entering this field is a proprietary arteriovenous coupler device that forms a …

Novel therapies to control blood pressure (BP) such as renal denervation, carotid baroreflex
activation and carotid body ablation address the sympathetic nervous system regulation of
the circulation. One of the more recent technologies to have made a debut is a proprietary
coupler device that forms a fixed calibre arteriovenous anastomosis in the central
vasculature and thus primarily targets mechanical aspects of the circulation. Here we
discuss the development of and rationale for the creation of a central arteriovenous …