Cerebellar ataxia in non-paraneoplastic Lambert–Eaton myasthenic syndrome
PJ Lorenzoni, RH Scola, B Lang, CSK Kay… - Journal of the …, 2008 - Elsevier
Lambert–Eaton myasthenic syndrome (LEMS) is an immune-mediated disorder of the
neuromuscular junction that rarely is associated with cerebellar ataxia (CA). We describe
two patients with non-paraneoplastic LEMS associated with CA who showed high levels of
anti-P/Q-type voltage-gated calcium channels antibodies in the serum and cerebrospinal
fluid, and reduced CMAP with increment after brief maximum voluntary contraction in
electrophysiological studies. We suggest that LEMS should be considered in the differential …
neuromuscular junction that rarely is associated with cerebellar ataxia (CA). We describe
two patients with non-paraneoplastic LEMS associated with CA who showed high levels of
anti-P/Q-type voltage-gated calcium channels antibodies in the serum and cerebrospinal
fluid, and reduced CMAP with increment after brief maximum voluntary contraction in
electrophysiological studies. We suggest that LEMS should be considered in the differential …